Socs2 Gene Summary [Mouse]
Enables growth hormone receptor binding activity and phosphorylation-dependent protein binding activity. Involved in negative regulation of growth hormone receptor signaling pathway. Acts upstream of or within several processes, including mammary gland development; negative regulation of receptor signaling pathway via JAK-STAT; and positive regulation of neuron differentiation. Predicted to be located in cytoplasm. Predicted to be part of Cul5-RING ubiquitin ligase complex. Is expressed in several structures, including leg; retina; spleen; testis; and ureteric tip. Human ortholog(s) of this gene implicated in endometrial cancer and ovarian carcinoma. Orthologous to human SOCS2 (suppressor of cytokine signaling 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Socs2 |
| Official Name | suppressor of cytokine signaling 2 [Source:MGI Symbol;Acc:MGI:1201787] |
| Ensembl ID | ENSMUSG00000020027 |
| Bio databases IDs | |
| Aliases | suppressor of cytokine signaling 2 |
| Synonyms | 8030460M17, CIS2, Cish2, D130043N08RIK, hg, JAB, SSI-2, STATI2, suppressor of cytokine signaling 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Socs2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- pre-SH2 domain
- elongin B/C binding domain
- protein binding activity, bridging
- Src homology 2 (SH2) domain
- SOCS
- protein binding
- JAK pathway signal transduction adaptor
- growth hormone receptor binding
- insulin-like growth factor receptor binding
Pathways
Biological processes and signaling networks where the Socs2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- high grade glioma
- glioblastoma cancer
- glioma cancer
- epithelial cancer
- metastasis
- liver cancer
- psoriasis
- hepatocellular carcinoma
- non-insulin-dependent diabetes mellitus
role in cell
- expression in
- proliferation
- growth
- outgrowth
- apoptosis
- activation in
- signaling in
- phosphorylation in
- cell viability
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Socs2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- growth hormone receptor signaling pathway
- negative regulation of multicellular organism growth
- positive regulation of neuron differentiation
- phosphatidylinositol phosphorylation
- lactation
- regulation of signal transduction
- negative regulation of JAK-STAT cascade
- JAK-STAT cascade
- mammary gland alveolus development
- regulation of cell growth
- negative regulation of apoptotic process
- response to estradiol stimulus
- cellular response to hormone stimulus
- intracellular signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- JAK pathway signal transduction adaptor activity
- growth hormone receptor binding
- 1-phosphatidylinositol-3-kinase regulator activity
- insulin-like growth factor receptor binding