Dhrs7b Gene Summary [Mouse]
Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in ether lipid biosynthetic process and neutrophil differentiation. Acts upstream of or within several processes, including brown fat cell differentiation; phosphatidylcholine biosynthetic process; and regulation of cold-induced thermogenesis. Located in membrane; nucleus; and peroxisome. Part of transcription regulator complex. Orthologous to human DHRS7B (dehydrogenase/reductase 7B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dhrs7b |
| Official Name | dehydrogenase/reductase (SDR family) member 7B [Source:MGI Symbol;Acc:MGI:2384931] |
| Ensembl ID | ENSMUSG00000042569 |
| Bio databases IDs | |
| Aliases | dehydrogenase/reductase (SDR family) member 7B |
| Synonyms | BC003479, C79874, C80074, CGI-93, dehydrogenase/reductase 7B, Dehydrogenase/reductase (SDR family) member 7B, LOC100045214, PexRAP, RGD1311243, SDR32C1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dhrs7b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- polyketide synthase keto reductase domain
- Rossmann-fold NAD(P)(+)-binding proteins
- transcription co-repressor
- acylglycerone-phosphate reductase
- KR domain
- transcription factor binding
- enzyme
- protein binding
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
- Alanine dehydrogenase/PNT, C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gliosis
regulates
- GSK3
- phosphatidylcholine
- GSK3A
- ether lipid
- renin
- ethanolamine plasmalogens
- 18:0p/22:6 phosphatidylethanolamine-plasmalogen
role in cell
- phosphorylation in
- differentiation
- area
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dhrs7b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- brown fat cell differentiation
- inflammatory response
- negative regulation of transcription, DNA-dependent
- neutrophil differentiation
- phosphatidylcholine biosynthetic process
- adipose tissue development
- ether lipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- peroxisomal membrane
- transcription factor complex
- nucleus
- membrane
Molecular Function
What the gene product does at the molecular level
- acylglycerone-phosphate reductase activity
- transcription corepressor activity