Mettl5 Gene Summary [Mouse]
Enables rRNA (adenine-N6-)-methyltransferase activity. Involved in positive regulation of translation; rRNA methylation; and stem cell differentiation. Predicted to be located in several cellular components, including fibrillar center; postsynapse; and presynapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 72. Orthologous to human METTL5 (methyltransferase 5, N6-adenosine). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mettl5 |
| Official Name | methyltransferase like 5 [Source:MGI Symbol;Acc:MGI:1922672] |
| Ensembl ID | ENSMUSG00000051730 |
| Bio databases IDs | |
| Aliases | methyltransferase like 5 |
| Synonyms | 2810410A08Rik, HSPC133, LOC100046143, methyltransferase 5, N6-adenosine, MRT72, RGD1566062 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mettl5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- rRNA (adenine-N6-)-methyltransferase
- binding protein
- enzyme
- protein binding
- methyltransferase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive intellectual developmental disorder 72
- organismal death
- craniofacial abnormality
role in cell
- binding in
- differentiation
- translation in
- pluripotency
- N6-methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- presynaptic regions
- postsynaptic region
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mettl5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- stem cell differentiation
- rRNA methylation
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleolus
- cell projection
- fibrillar center
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding
- rRNA (adenine-N6-)-methyltransferase activity