Cops7b Gene Summary [Mouse]
Predicted to be involved in protein deneddylation. Predicted to be located in nucleoplasm. Predicted to be part of COP9 signalosome. Is expressed in central nervous system; extraembryonic component; sensory organ; and skeleton. Orthologous to human COPS7B (COP9 signalosome subunit 7B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cops7b |
| Official Name | COP9 signalosome subunit 7B [Source:MGI Symbol;Acc:MGI:1349388] |
| Ensembl ID | ENSMUSG00000026240 |
| Bio databases IDs | |
| Aliases | COP9 signalosome subunit 7B |
| Synonyms | COP9 signalosome subunit 7B, CSN7B, D1Wsu66e, E130114M23, SGN7b |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cops7b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- COP9 signalosome complex subunit 7a helix I domain
- protein binding
Pathways
Biological processes and signaling networks where the Cops7b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- metastasis
- aortic valve calcification
role in cell
- expression in
- phosphorylation in
- CSN5i-3 sensitivity
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cops7b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deneddylation
- signalosome assembly
- regulation of protein neddylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- signalosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding