Rspo2 Gene Summary [Mouse]
Enables heparin binding activity. Acts upstream of or within several processes, including embryonic limb morphogenesis; negative regulation of odontogenesis of dentin-containing tooth; and respiratory system development. Located in cell surface and extracellular region. Is expressed in several structures, including brain; jaw; limb; pelvic urethra; and sensory organ. Human ortholog(s) of this gene implicated in tetraamelia syndrome 2. Orthologous to human RSPO2 (R-spondin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rspo2 |
| Official Name | R-spondin 2 [Source:MGI Symbol;Acc:MGI:1922667] |
| Ensembl ID | ENSMUSG00000051920 |
| Bio databases IDs | |
| Aliases | R-spondin 2 |
| Synonyms | 2610028F08Rik, CRISTIN2, D430027K22, ftls, HHRRD, RGD1562331, R-spondin 2, TETAMS2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rspo2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FU
- Furin-like repeat, cysteine-rich
- Furin-like repeats
- protein binding
- receptor binding
- Spondin-like TSP1 domain
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- prostate cancer
- epithelial cancer
- alopecia
- acute lymphoblastic leukemia
- prostatic carcinoma
- tetraamelia syndrome 2
- aortic valve calcification
- tumorigenesis
- hypoplasia
phenotypes
- abnormal apical ectodermal ridge morphology
- abnormal autopod morphology
- abnormal bone ossification
- abnormal digestive system development
- abnormal digit morphology
- abnormal forelimb morphology
- abnormal forelimb zeugopod morphology
- abnormal hindlimb morphology
- abnormal kidney development
- abnormal laryngeal cartilage morphology
- abnormal limb development
- abnormal limb morphology
- abnormal lung morphology
- abnormal lung vasculature morphology
- abnormal mandibular angle morphology
- abnormal maxilla morphology
- abnormal maxillary shelf morphology
- abnormal maxillary zygomatic process morphology
- abnormal nail morphology
- abnormal ovulation
- abnormal palatal shelf elevation
- abnormal palatal shelf fusion at midline
- abnormal phalanx morphology
- abnormal pharyngeal arch mesenchyme morphology
- abnormal pulmonary alveolus morphology
- abnormal temporal bone squamous part morphology
- abnormal tooth development
- abnormal tracheal cartilage morphology
- abnormal zygomatic bone morphology
- absence of all nails
- absent fibula
- absent kidney
- absent mandibular coronoid process
- absent radius
- absent tibia
- arytenoid and cricoid cartilage fusion
- brachyphalangia
- cleft palate
- cleft secondary palate
- cleft upper lip
- cyanosis
- decreased palatine bone horizontal plate size
- decreased tongue size
- decreased tympanic ring size
- delayed kidney development
- growth retardation of incisors
- lung hemorrhage
- maxillary shelf hypoplasia
- neonatal lethality complete penetrance
- oligodactyly
- ovary cysts
- palatal shelves fail to meet at midline
- perinatal lethality complete penetrance
- pulmonary hypoplasia
- reduced female fertility
- respiratory failure
- short Meckel's cartilage
- short fibula
- short mandible
- short metatarsal bones
- short tibia
- single kidney
- small mandible
- small mandibular condyloid process
- small maxilla
- syndactyly
role in cell
- expression in
- signaling in
- differentiation
- maturation
- hypertrophy
- mineralization
- expansion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rspo2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial tube branching involved in lung morphogenesis
- bone mineralization
- limb development
- positive regulation of canonical Wnt receptor signaling pathway
- lung growth
- negative regulation of odontogenesis of dentin-containing tooth
- trachea cartilage morphogenesis
- dopaminergic neuron differentiation
- osteoblast differentiation
- canonical Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway
- embryonic forelimb morphogenesis
- embryonic hindlimb morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- heparin binding
- receptor binding