Phf10 Gene Summary [Mouse]
Predicted to enable chromatin binding activity; histone acetyltransferase activity; and transcription coregulator activity. Involved in nervous system development. Part of npBAF complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and tooth. Orthologous to human PHF10 (PHD finger protein 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phf10 |
| Official Name | PHD finger protein 10 [Source:MGI Symbol;Acc:MGI:1919307] |
| Ensembl ID | ENSMUSG00000023883 |
| Bio databases IDs | |
| Aliases | PHD finger protein 10 |
| Synonyms | 1810055P05RIK, BAF45A, LOC106740, PHD finger protein 10, SMARCG4, XAP135 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phf10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- WH_NTD_SMARCB1_like
- PHD finger superfamily
- protein binding
Pathways
Biological processes and signaling networks where the Phf10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phf10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- regulation of mitotic metaphase/anaphase transition
- positive regulation of T cell differentiation
- nervous system development
- positive regulation of myoblast differentiation
- positive regulation of cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- regulation of nucleotide-excision repair
- positive regulation of double-strand break repair
- regulation of G0 to G1 transition
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- SWI/SNF complex
- npBAF complex
- nuclear matrix
- kinetochore
- RSC complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase activity
- transcription cofactor activity
- metal ion binding
- chromatin binding