Parp12 Gene Summary [Mouse]
Predicted to enable NAD+ poly-ADP-ribosyltransferase activity and NAD+-protein mono-ADP-ribosyltransferase activity. Predicted to be involved in protein auto-ADP-ribosylation. Predicted to be active in nucleus. Is expressed in early conceptus; gallbladder; genitourinary system; and gut. Orthologous to human PARP12 (poly(ADP-ribose) polymerase family member 12). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Parp12 |
| Official Name | poly (ADP-ribose) polymerase family, member 12 [Source:MGI Symbol;Acc:MGI:2143990] |
| Ensembl ID | ENSMUSG00000038507 |
| Bio databases IDs | |
| Aliases | poly (ADP-ribose) polymerase family, member 12 |
| Synonyms | 9930021O16, AA409132, AA536654, ARTD12, FLJ22693, MST109, MSTP109, poly (ADP-ribose) polymerase family, member 12, poly(ADP-ribose) polymerase family member 12, ZC3H1, ZC3HDC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Parp12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger
- Domain in Deltex and TRIP12 homologues
- pentosyltransferase
- catalytic domain
- Poly(ADP-ribose) polymerase catalytic domain
- WWE domain
- enzyme
- ADP_ribosyl
Pathways
Biological processes and signaling networks where the Parp12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- Huntington disease
- myocardial infarction
- systemic lupus erythematosus nephritis
- myelodysplastic bone marrow neoplasm
- myelodysplastic syndrome
- vitiligo
role in cell
- replication in
- expression in
- exiting in
- ADP ribosylation in
- translation in
- retention in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Parp12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein auto-ADP-ribosylation
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- nucleotidyltransferase activity
- RNA binding
- metal ion binding
- NAD+ ADP-ribosyltransferase activity