Ilkap Gene Summary [Mouse]
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in regulation of nuclear cell cycle DNA replication and signal transduction. Predicted to be located in cytoplasm. Is expressed in central nervous system; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human ILKAP (ILK associated serine/threonine phosphatase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Ilkap |
| Official Name | integrin-linked kinase-associated serine/threonine phosphatase 2C [Source:MGI Symbol;Acc:MGI:1914694] |
| Ensembl ID | ENSMUSG00000026309 |
| Bio databases IDs | |
| Aliases | integrin-linked kinase-associated serine/threonine phosphatase 2C |
| Synonyms | 0710007A14RIK, 1600009O09Rik, AF095927, AK055417, ILKAP2, ILKAP3, ILK associated serine/threonine phosphatase, integrin-linked kinase-associated serine/threonine phosphatase 2C, PP2C-D, PP2C-DELTA, PP2C-δ, PPM1O |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ilkap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein phosphatase 2C
- catalytic domain
- protein serine/threonine phosphatase
- phosphatase
- protein binding
- Serine/threonine phosphatases, family 2C, catalytic domain
- PP2Cc
Pathways
Biological processes and signaling networks where the Ilkap gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- Alzheimer disease
- breast cancer
- chronic lymphocytic leukemia
role in cell
- expression in
- activation in
- apoptosis
- phosphorylation in
- growth
- binding in
- differentiation
- size
- glycolysis in
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ilkap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- myosin phosphatase activity