Lama5

Enables integrin binding activity. Involved in postsynapse organization. Acts upstream of or within several processes, including hair follicle development; morphogenesis of an epithelium; and trunk neural crest cell migration. Located in extracellular matrix. Part of laminin-10 complex. Is active in several cellular components, including extracellular matrix of synaptic cleft; glutamatergic synapse; and synaptic cleft. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; salivary gland primordium; and sensory organ. Used to study cystic kidney disease. Human ortholog(s) of this gene implicated in bent bone dysplasia syndrome 2 and familial nephrotic syndrome. Orthologous to human LAMA5 (laminin subunit alpha 5). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lama5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Lama5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Lama5 gene, providing context for its role in the cell.