Lamb2 Gene Summary [Mouse]
Enables integrin binding activity. A structural constituent of synapse-associated extracellular matrix. Acts upstream of or within several processes, including metanephric glomerulus development; neurogenesis; and visual perception. Located in basement membrane and synapse. Part of laminin-3 complex. Is active in neuromuscular junction and synaptic cleft. Is expressed in several structures, including Reichert's membrane; alimentary system; brain; decidua; and submandibular gland primordium. Used to study Pierson syndrome and nephrosis. Human ortholog(s) of this gene implicated in Pierson syndrome; nephrotic syndrome type 5; and primary open angle glaucoma. Orthologous to human LAMB2 (laminin subunit beta 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lamb2 |
| Official Name | laminin, beta 2 [Source:MGI Symbol;Acc:MGI:99916] |
| Ensembl ID | ENSMUSG00000052911 |
| Bio databases IDs | |
| Aliases | laminin, beta 2 |
| Synonyms | Beta laminin, Laminin beta 2, laminin, beta 2, LAMININ S, laminin subunit beta 2, laminin subunit β 2, Laminin β 2, laminin, β 2, LAMS, NPHS5, npht, PIERS, SLAM, β laminin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lamb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- laminin domain VI
- Nuf2, DHR10-like domain
- Flagellar FliJ protein
- F-type ATP synthase, membrane subunit b
- enzyme
- Bin/Amphiphysin/Rvs domain
- Protein of unknown function (DUF745)
- Type III secretion protein YscO
- ATP synthase B/B' CF(0)
- EGF_CA
- Laminin Domain I
- Domain of unknown function (DUF4398)
- Laminin-type epidermal growth factor-like domai
- Tropomyosin
- Vacuolar (H+)-ATPase G subunit
- C-terminal coiled-coil domain found in the laminin subunit beta (LAMB) family
- SPEC
- Laminin N-terminal (Domain VI)
- laminin domain V
- Ezrin/radixin/moesin, alpha-helical domain
- PspA/IM30 family
- extracellular matrix structural constituent
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Helical bimodular sensor domain
- FlgN protein
- Domain of unknown function (DUF4659)
- Mechanosensitive ion channel porin domain
- Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)
- Methyl-accepting chemotaxis protein (MCP), signaling domain
- Domain of unknown function (DUF6468)
- Trichohyalin-plectin-homology domain
- integrin binding
- Intermediate filament protein
- Apolipoprotein A1/A4/E domain
- Family of unknown function (DUF6781)
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the Lamb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast carcinoma
- myocardial infarction
- androgenic alopecia
- hereditary disorder
- nephrotic syndrome type 5 without ocular abnormalities
- Pierson syndrome
- Alzheimer disease
- nephrotic syndrome type 5 with ocular abnormalities
- nephrosis
role in cell
- expression in
- activation in
- apoptosis
- proliferation
- phosphorylation in
- length
- number
- morphology
- growth
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- synaptic cleft
- endoplasmic reticulum lumen
- Golgi membrane
- neuromuscular junctions
- synapse
- extracellular matrix
- basal lamina
- axon terminals
- ribbon synapse
- interphotoreceptor matrix
- basement membrane
- glomerular basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lamb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astrocyte development
- Schwann cell development
- retina development in camera-type eye
- axon guidance
- cell adhesion
- positive regulation of cell adhesion
- axon extension involved in regeneration
- visual perception
- neuromuscular junction development
- metanephric glomerular basement membrane development
- metanephric glomerular visceral epithelial cell development
- positive regulation of integrin-mediated signaling pathway
- positive regulation of muscle cell differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- basement membrane
- laminin-11 complex
- synaptic cleft
- extracellular vesicular exosome
- laminin-3 complex
- neuromuscular junction
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity
- integrin binding
- extracellular matrix structural constituent