Mllt11 Gene Summary [Mouse]
Predicted to be involved in several processes, including apoptotic signaling pathway; positive regulation of mitochondrial depolarization; and positive regulation of release of cytochrome c from mitochondria. Located in cytoplasm. Is expressed in several structures, including gut; nervous system; nose; retina; and secondary oocyte. Orthologous to human MLLT11 (MLLT11 transcription factor 7 cofactor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mllt11 |
| Official Name | myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 [Source:MGI Symbol;Acc:MGI:1929671] |
| Ensembl ID | ENSMUSG00000053192 |
| Bio databases IDs | |
| Aliases | myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 |
| Synonyms | AF1Q, MLLT11 transcription factor 7 cofactor, MLLT11, transcription factor 7 cofactor, myeloid/lymphoid or mixed-lineage leukaemia; translocated to, 11, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11, RGD1305525, Zfp692 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mllt11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative WW-binding domain and destruction box
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- schizophrenia
- endometrial carcinoma
- rotator cuff injury
- organismal death
- endometriosis
- mucopolysaccharidosis type IVB
- HER2 negative hormone receptor negative breast cancer
- androgenic alopecia
- hematological disorder
role in cell
- invasion by
- proliferation
- migration
- expression in
- apoptosis
- number
- adhesion
- accumulation
- differentiation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pericentrosomal region
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mllt11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- positive regulation of apoptotic process
- positive regulation of release of cytochrome c from mitochondria
- extrinsic apoptotic signaling pathway
- positive regulation of mitochondrial depolarization
- intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding