Ndfip2 Gene Summary [Mouse]
Predicted to enable WW domain binding activity. Predicted to be involved in negative regulation of transport; regulation of macromolecule metabolic process; and ubiquitin-dependent protein catabolic process. Predicted to be located in membrane and mitochondrion. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; gut; lower urinary tract; sensory organ; and submandibular gland primordium. Orthologous to human NDFIP2 (Nedd4 family interacting protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndfip2 |
| Official Name | Nedd4 family interacting protein 2 [Source:MGI Symbol;Acc:MGI:1923523] |
| Ensembl ID | ENSMUSG00000053253 |
| Bio databases IDs | |
| Aliases | Nedd4 family interacting protein 2 |
| Synonyms | 0710001O20Rik, 2810436B12RIK, 9130207N19Rik, mKIAA1165, N4WBP5A, Nedd4 family interacting protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndfip2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- NEDD4 family-interacting protein
- WW domain binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- Golgi membrane
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndfip2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein transport
- negative regulation of gene expression
- positive regulation of protein ubiquitination
- negative regulation of transporter activity
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- vacuolar transport
- metal ion transport
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- mitochondrion
- Golgi apparatus
- Golgi membrane
- endoplasmic reticulum
- multivesicular body membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- WW domain binding