Dis3l2 Gene Summary [Mouse]
Enables 3'-5'-RNA exonuclease activity; magnesium ion binding activity; and poly(U) RNA binding activity. Involved in miRNA catabolic process and stem cell population maintenance. Located in cytoplasm. Is expressed in several structures, including central nervous system; ganglia; metanephros; molar; and nose. Used to study Perlman syndrome. Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Dis3l2 |
| Official Name | DIS3 like 3'-5' exoribonuclease 2 [Source:MGI Symbol;Acc:MGI:2442555] |
| Ensembl ID | ENSMUSG00000053333 |
| Bio databases IDs | |
| Aliases | DIS3 like 3'-5' exoribonuclease 2 |
| Synonyms | 4930429A22RIK, 8030493P09Rik, DIS3-like 3'-5' exoribonuclease 2, FAM6A, hDIS3L2, MGC42174, PRLMNS, RGD1560168 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dis3l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dis3-like cold-shock domain 2 (CSD2)
- Rrp44-like cold shock domain
- VacB and RNase II family 3'-5' exoribonucleases
- enzyme
- protein binding
- magnesium ion binding
- This domain is the catalytic domain of ribonuclease II
- poly(U) binding protein
- DIS3-like exonuclease 2 C terminal
- 3'-5' exoribonuclease
- ribonuclease R
- RNB domain
- ribonuclease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- Perlman syndrome
- organismal death
- colorectal cancer
- backache
- hepatocellular carcinoma
- Wilms tumor
- Wilms tumorigenesis
regulated by
- Bacillus anthracis Sterne strain 7702
- let-7 (includes others)
- MYOC
role in cell
- cell viability
- expression in
- quantity
- proliferation
- binding in
- phosphorylation in
- migration
- invasion by
- degradation in
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- Nucleus
- polysomes
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dis3l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- stem cell maintenance
- negative regulation of cell proliferation
- nuclear-transcribed mRNA catabolic process
- mRNA catabolic process
- mitotic sister chromatid separation
- miRNA catabolic process
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytoplasmic mRNA processing body
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- 3'-5'-exoribonuclease activity
- protein binding
- ribonuclease activity
- poly(U) RNA binding