E2f7 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including hepatocyte differentiation; regulation of cell cycle process; and trophoblast giant cell differentiation. Acts upstream of or within negative regulation of cell population proliferation and regulation of DNA-templated transcription. Located in nucleus. Is expressed in brain; embryo mesenchyme; and genitourinary system. Orthologous to human E2F7 (E2F transcription factor 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | E2f7 |
| Official Name | E2F transcription factor 7 [Source:MGI Symbol;Acc:MGI:1289147] |
| Ensembl ID | ENSMUSG00000020185 |
| Bio databases IDs | |
| Aliases | E2F transcription factor 7 |
| Synonyms | A630014C11Rik, D10ERTD739E, E2F transcription factor 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse E2f7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- nucleic acid binding
- double-stranded DNA binding
- E2F/DP family winged-helix DNA-binding domain
- protein binding
- sequence-specific DNA binding
- transcription factor activity
- identical protein binding
Pathways
Biological processes and signaling networks where the E2f7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- Cell Cycle Regulation by BTG Family Proteins
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- DNA Methylation and Transcriptional Repression Signaling
- Estrogen-mediated S-phase Entry
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Role of BRCA1 in DNA Damage Response
- Role of CHK Proteins in Cell Cycle Checkpoint Control
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- epithelial cancer
- endometrial adenocarcinoma
- bleeding
- nonsyndromic cleft lip and palate
- tumorigenesis
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung squamous cell carcinoma
role in cell
- expression in
- apoptosis
- proliferation
- migration
- differentiation
- recruitment in
- transactivation in
- ploidy
- S phase
- Gap 0-Gap 1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse E2f7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- sprouting angiogenesis
- placenta development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- hepatocyte differentiation
- chorionic trophoblast cell differentiation
- trophoblast giant cell differentiation
- negative regulation of G1/S transition of mitotic cell cycle
- negative regulation of cytokinesis
- positive regulation of DNA endoreduplication
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity