Nrd1 Gene Summary [Mouse]
Predicted to enable peptidase activity. Involved in negative regulation of cold-induced thermogenesis; positive regulation of membrane protein ectodomain proteolysis; and regulation of nervous system development. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; nose; and spleen. Orthologous to human NRDC (nardilysin convertase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrd1 |
| Official Name | nardilysin, N-arginine dibasic convertase, NRD convertase 1 [Source:MGI Symbol;Acc:MGI:1201386] |
| Ensembl ID | ENSMUSG00000053510 |
| Bio databases IDs | |
| Aliases | nardilysin, N-arginine dibasic convertase, NRD convertase 1 |
| Synonyms | 2600011I06Rik, hNRD1, hNRD2, nardilysin, nardilysin convertase, NRD1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hormone binding
- peptidase
- Middle or third domain of peptidase_M16
- protein binding
- enzyme regulator activity
- Insulinase (Peptidase family M16)
- protease activator
- Peptidase M16 inactive domain
- acidic domain
- growth factor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- bradycardia
- hypoplasia
- major depression
- Hutchinson-Gilford progeria syndrome
- focal cortical dysplasia type I
- abdominal aortic aneurysm
regulated by
- cocaine
- spermine
- atorvastatin
role in cell
- production in
- proliferation
- migration
- formation
- adhesion
- stabilization in
- translocation in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Mitochondria
- cytosol
- mitochondrial matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of axonogenesis
- positive regulation of membrane protein ectodomain proteolysis
- proteolysis
- regulation of endopeptidase activity
- positive regulation of myelination
Cellular Component
Where in the cell the gene product is active
- dendrite
- mitochondrion
- cytosol
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- metalloendopeptidase activity
- epidermal growth factor binding