Lpin2 Gene Summary [Mouse]
Enables phosphatidate phosphatase activity and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II and triglyceride biosynthetic process. Located in cytosol and endoplasmic reticulum membrane. Is expressed in central nervous system; gonad; liver; lung; and retina. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis. Orthologous to human LPIN2 (lipin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Lpin2 |
| Official Name | lipin 2 [Source:MGI Symbol;Acc:MGI:1891341] |
| Ensembl ID | ENSMUSG00000024052 |
| Bio databases IDs | |
| Aliases | lipin 2 |
| Synonyms | 2610511G02Rik, CRMO1, Lipin 2, MJDS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lpin2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription co-activator
- Lipin/Ned1/Smp2 multi-domain protein middle domain
- phosphatidate phosphatase
- phosphatase
- LNS2 (Lipin/Ned1/Smp2)
- lipin, N-terminal conserved region
- Haloacid Dehalogenase-like Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Majeed syndrome
- lung cancer
- non-insulin-dependent diabetes mellitus
- obesity
- chronic lymphocytic leukemia
- bullous pemphigoid
- autoinflammatory disorder
- diabetes mellitus
- global developmental delay with intellectual disability
role in cell
- production in
- expression in
- volume
- adipogenesis
- accumulation in
- fat storage capacity
- fragmentation in
- fragmentation
- co-activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lpin2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- fatty acid catabolic process
- lipid metabolic process
- triglyceride biosynthetic process
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- phosphatidate phosphatase activity
- transcription coactivator activity