Mepe Gene Summary [Mouse]
Predicted to enable extracellular matrix protein binding activity. Acts upstream of or within negative regulation of bone mineralization. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including aorta; bone; connective tissue; lower jaw mesenchyme; and lower leg mesenchyme. Orthologous to human MEPE (matrix extracellular phosphoglycoprotein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mepe |
| Official Name | matrix extracellular phosphoglycoprotein with ASARM motif (bone) [Source:MGI Symbol;Acc:MGI:2137384] |
| Ensembl ID | ENSMUSG00000053863 |
| Bio databases IDs | |
| Aliases | matrix extracellular phosphoglycoprotein with ASARM motif (bone) |
| Synonyms | matrix extracellular phosphoglycoprotein, matrix extracellular phosphoglycoprotein with ASARM motif (bone), OF45 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mepe often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Osteoregulin
- extracellular matrix structural constituent
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mepe gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- extracellular matrix structural constituent