Utp18 Gene Summary [Mouse]
Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be located in nuclear membrane; nucleolus; and nucleoplasm. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is expressed in heart. Orthologous to human UTP18 (UTP18 small subunit processome component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Utp18 |
| Official Name | UTP18 small subunit processome component [Source:MGI Symbol;Acc:MGI:1923402] |
| Ensembl ID | ENSMUSG00000054079 |
| Bio databases IDs | |
| Aliases | UTP18 small subunit processome component |
| Synonyms | 6230425C22Rik, 6430513M13, CGI-48, RGD1309957, UTP18 small subunit processome component, WDR50 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Utp18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- melanoma
- melanoma cancer
- breast carcinoma
- tumorigenesis
- neuroblastoma
- neuroblastoma formation
- organismal death
- neoplastic cell transformation
role in cell
- expression in
- apoptosis
- production in
- accumulation in
- translation in
- molecular cleavage in
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pre-ribosome
- Cytoplasm
- polysomes
- nucleoplasm
- nucleoli
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Utp18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosomal small subunit biogenesis
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- nucleus
- nuclear membrane
- Pwp2p-containing subcomplex of 90S preribosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding