Chst4 Gene Summary [Mouse]
Enables N-acetylglucosamine 6-O-sulfotransferase activity. Involved in positive regulation of leukocyte tethering or rolling. Acts upstream of or within leukocyte tethering or rolling and protein sulfation. Predicted to be located in Golgi membrane. Predicted to be active in trans-Golgi network. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver; and nervous system. Orthologous to human CHST4 (carbohydrate sulfotransferase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chst4 |
| Official Name | carbohydrate sulfotransferase 4 [Source:MGI Symbol;Acc:MGI:1349479] |
| Ensembl ID | ENSMUSG00000035930 |
| Bio databases IDs | |
| Aliases | carbohydrate sulfotransferase 4 |
| Synonyms | carbohydrate sulfotransferase 4, carbohydrate sulphotransferase 4, GLCNAC6ST2, Gn6st-2, GST-3, Hec-6st, HECGLCNAC6ST, LSST |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chst4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfotransferase
- N-acetylglucosamine-6-O-sulfotransferase
- enzyme
- Sulfotransferase family
Pathways
Biological processes and signaling networks where the Chst4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- sneeze
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
role in cell
- binding
- migration
- adhesion
- number
- cell rolling
- quantity
- cell tethering or rolling by
- cell tethering or rolling
- homing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- Golgi Apparatus
- Endoplasmic Reticulum
- Golgi membrane
- trans Golgi network
- medial Golgi cisternae
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chst4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- inflammatory response
- immune response
- sulfur compound metabolic process
- cell-cell signaling
- N-acetylglucosamine metabolic process
- cell adhesion
- O-glycan processing
- protein sulfation
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- N-acetylglucosamine 6-O-sulfotransferase activity
- sulfotransferase activity