Tnfsf18 Gene Summary [Mouse]
Enables identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; regulation of T cell activation; and regulation of leukocyte chemotaxis. Located in cell surface. Is expressed in skin; submandibular gland; and thyroid gland. Orthologous to human TNFSF18 (TNF superfamily member 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfsf18 |
| Official Name | tumor necrosis factor (ligand) superfamily, member 18 [Source:MGI Symbol;Acc:MGI:2673064] |
| Ensembl ID | ENSMUSG00000066755 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor (ligand) superfamily, member 18 |
| Synonyms | AITRL, GITRL, hGITRL, TEASRL, TL6, TNF superfamily member 18, TNLG2A, tumor necrosis factor (ligand) superfamily, member 18, tumour necrosis factor (ligand) superfamily, member 18 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfsf18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- extracellular domain
- TNF homology domain
- TNF
- protein binding
- receptor binding
- cytokine
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- expression in
- activation in
- apoptosis
- proliferation
- phosphorylation in
- production in
- chemotaxis
- number
- migration
- frequency
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfsf18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of T cell proliferation
- positive regulation of leukocyte migration
- tumor necrosis factor-mediated signaling pathway
- signal transduction
- negative regulation of apoptotic process
- T cell proliferation involved in immune response
- cell-cell signaling
- adaptive immune response
- positive regulation of cell adhesion
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- tumor necrosis factor receptor superfamily binding
- cytokine activity
- receptor binding