Dedd Gene Summary [Mouse]
Enables DNA binding activity. Acts upstream of or within decidualization; extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of macromolecule metabolic process. Located in cytoplasm and nucleolus. Is expressed in central nervous system and retina. Orthologous to human DEDD (death effector domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dedd |
| Official Name | death effector domain-containing [Source:MGI Symbol;Acc:MGI:1333874] |
| Ensembl ID | ENSMUSG00000013973 |
| Bio databases IDs | |
| Aliases | death effector domain-containing |
| Synonyms | CASP8IP1, death effector domain-containing, DEDD1, DEDPro1, DEFT, FLDED-1, KE05 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dedd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death effector domain
- nuclear localization sequence
- protein binding
- Death Domain Superfamily of protein-protein interaction domains
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dedd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- negative regulation of protein catabolic process
- decidualization
- regulation of apoptotic process
- induction of apoptosis via death domain receptors
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nucleolus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding