Rbfox2 Gene Summary [Mouse]
Enables mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome and regulation of definitive erythrocyte differentiation. Acts upstream of or within dendrite morphogenesis; neuromuscular process controlling balance; and radial glia guided migration of Purkinje cell. Located in nucleus. Is expressed in several structures, including blastocyst; brain; dorsal root ganglion; early embryo; and limb. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RBFOX2 (RNA binding fox-1 homolog 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbfox2 |
| Official Name | RNA binding protein, fox-1 homolog (C. elegans) 2 [Source:MGI Symbol;Acc:MGI:1933973] |
| Ensembl ID | ENSMUSG00000033565 |
| Bio databases IDs | |
| Aliases | RNA binding protein, fox-1 homolog (C. elegans) 2 |
| Synonyms | dJ106I20.3, FBM2, FOX2, Fxh, HNRBP2, HRNBP2, RBM9, Rbm9 (predicted), RNA binding fox-1 homolog 2, RNA binding protein, fox-1 homolog (C. elegans) 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbfox2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcitonin gene-related peptide regulator C terminal
- RNA recognition motif (RRM) superfamily
- transcription regulator
- RNA recognition motif
- mRNA binding
- transcription co-repressor
- nuclear localization sequence
- transcription factor binding
- protein binding
- single-stranded RNA binding
- RNA binding
Pathways
Biological processes and signaling networks where the Rbfox2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hypertension
- tumorigenesis
- hereditary disorder
- congenital heart disease
- organismal death
- specific language impairment
- impaired glucose tolerance
- suicide attempt
role in cell
- expression in
- migration
- growth
- proliferation
- apoptosis
- quantity
- differentiation
- firing
- morphology
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbfox2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- RNA metabolic process
- negative regulation of transcription, DNA-dependent
- regulation of alternative nuclear mRNA splicing, via spliceosome
- nervous system development
- mRNA processing
- intracellular estrogen receptor signaling pathway
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- transcription corepressor activity
- mRNA binding