EEF1D Gene Summary [Human]
This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | EEF1D |
| Official Name | eukaryotic translation elongation factor 1 delta [Source:HGNC Symbol;Acc:HGNC:3211] |
| Ensembl ID | ENSG00000104529 |
| Bio databases IDs | |
| Aliases | eukaryotic translation elongation factor 1 delta |
| Synonyms | 1700026P12RIK, Eef1 δ, EF1B beta, EF1B β, EF-1D, EF-1-delta, EF-1-δ, eukaryotic translation elongation factor 1 delta, eukaryotic translation elongation factor 1 δ, FP1047, Tef1 delta, Tef1 δ, UNQ601, δ Ef1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EEF1D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Eukaryotic elongation factor 1 beta central acidic region
- nucleic acid binding translation factor
- nucleic acid binding
- double-stranded DNA binding
- heat shock protein binding
- transcription factor binding
- protein binding
- zinc finger domain
- EF-1 guanine nucleotide exchange domain
- sequence-specific DNA binding
- EF1B
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- idiopathic scoliosis
- myelodysplastic syndrome with isolated del(5q)
- acne
- neurodevelopmental disorder
- cold thyroid nodule
- Moyamoya disease
- autosomal recessive nonsyndromic mental retardation
role in cell
- migration
- phosphorylation in
- proliferation
- apoptosis
- growth
- quantity
- transformation
- development
- oncogenic potential
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- fibrillar center
- endoplasmic reticulum mitochondria contact site
- Nucleus
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EEF1D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to ionizing radiation
- translational elongation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- endoplasmic reticulum
- fibrillar center
- eukaryotic translation elongation factor 1 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- translation elongation factor activity
- cadherin binding
- guanyl-nucleotide exchange factor activity
- translation factor activity, nucleic acid binding