Tcim Gene Summary [Mouse]
Predicted to enable Notch binding activity. Acts upstream of or within regulation of hemopoiesis. Located in cytoplasm and nucleus. Is expressed in lower jaw molar; nasal epithelium; olfactory epithelium; and upper jaw molar. Orthologous to human TCIM (transcriptional and immune response regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tcim |
| Official Name | transcriptional and immune response regulator [Source:MGI Symbol;Acc:MGI:1916318] |
| Ensembl ID | ENSMUSG00000056313 |
| Bio databases IDs | |
| Aliases | transcriptional and immune response regulator |
| Synonyms | 1110065B09Rik, 1810011O10Rik, AW321058, C8orf, C8orf4, TC-1, transcriptional and immune response regulator |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tcim often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thyroid cancer protein 1
- protein binding
- notch binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- ulcerative colitis
- neoplastic cell transformation
- lymphoid hyperplasia
- laryngeal squamous cell carcinoma
- squamous cell cancer of the larynx
- myeloid hyperplasia
role in cell
- proliferation
- expression in
- adhesion
- growth
- apoptosis
- abnormal morphology
- response by
- number
- permeability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tcim gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein kinase A signaling cascade
- cellular response to heat
- positive regulation of protein kinase C activity
- negative regulation of apoptotic process
- apoptotic process
- endothelial cell activation involved in immune response
- negative regulation of Notch signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- Notch binding