LOC684871 Gene Summary [Rat]
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | LOC684871 |
| Official Name | similar to Protein C8orf4 (Thyroid cancer protein 1) (TC-1) [Source:RGD Symbol;Acc:1585525] |
| Ensembl ID | ENSRNOG00000049811 |
| Bio databases IDs | |
| Aliases | similar to Protein C8orf4 (Thyroid cancer protein 1) (TC-1) |
| Synonyms | 1110065B09Rik, 1810011O10Rik, AW321058, C8orf, C8orf4, TC-1, transcriptional and immune response regulator |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc684871 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thyroid cancer protein 1
- protein binding
- notch binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- ulcerative colitis
- neoplastic cell transformation
- lymphoid hyperplasia
- laryngeal squamous cell carcinoma
- squamous cell cancer of the larynx
- myeloid hyperplasia
role in cell
- proliferation
- expression in
- adhesion
- growth
- apoptosis
- abnormal morphology
- response by
- number
- permeability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc684871 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein kinase A signaling cascade
- cellular response to heat
- positive regulation of protein kinase C activity
- negative regulation of apoptotic process
- apoptotic process
- endothelial cell activation involved in immune response
- negative regulation of Notch signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- Notch binding