Nbeal2 Gene Summary [Mouse]
Predicted to enable protein kinase binding activity. Acts upstream of or within blood coagulation; megakaryocyte development; and platelet alpha granule organization. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and membrane. Used to study gray platelet syndrome. Human ortholog(s) of this gene implicated in gray platelet syndrome. Orthologous to human NBEAL2 (neurobeachin like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nbeal2 |
| Official Name | neurobeachin-like 2 [Source:MGI Symbol;Acc:MGI:2448554] |
| Ensembl ID | ENSMUSG00000056724 |
| Bio databases IDs | |
| Aliases | neurobeachin-like 2 |
| Synonyms | 1110014F23Rik, BDPLT4, GPS, KIAA0540, mKIAA0540, Nbeal2-ps1, neurobeachin-like 2, RGD1306501 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nbeal2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- Domain of unknown function (DUF4800)
- Neurobeachin beta propeller domain
- WD domain, G-beta repeat
- WD40
- protein binding
- Pleckstrin homology-like domain
- Beach
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gray platelet syndrome
- thrombocytopenia
- metastasis
- bleeding
- splenomegaly
- productive infection by HIV-1
role in cell
- activation in
- binding in
- aggregation
- expression in
- proliferation
- number
- formation
- quantity
- activation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Endoplasmic Reticulum
- secretory granule membrane
- tertiary granule membrane
- recycling endosomes
- cytoplasmic vesicles
- lysosome-related organelle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nbeal2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization
- platelet formation
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- endoplasmic reticulum
- plasma membrane
- tertiary granule membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding