SKAP1 Gene Summary [Human]
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SKAP1 |
| Official Name | src kinase associated phosphoprotein 1 [Source:HGNC Symbol;Acc:HGNC:15605] |
| Ensembl ID | ENSG00000141293 |
| Bio databases IDs | |
| Aliases | src kinase associated phosphoprotein 1 |
| Synonyms | 1700091G21Rik, HEL-S-81p, SCAP1, SKAP55, src family associated phosphoprotein 1, src kinase associated phosphoprotein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SKAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- binding protein
- protein kinase binding
- SH2-domain binding
- protein phosphatase binding
- PH domain
- protein binding
- Pleckstrin homology-like domain
- SH3-domain binding
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the SKAP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inflammatory bowel disease
- schizophrenia
- prostate cancer
- gastric cancer
- esophageal carcinoma formation
- organismal death
- chronic fatigue syndrome
- ovarian carcinoma
- epithelial ovarian cancer
- keratoconus
role in cell
- binding in
- expression in
- proliferation
- phosphorylation in
- migration
- development
- adhesion
- invasion by
- interaction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular compartment
- intracellular space
- cellular membrane
- Plasma Membrane
- intercellular junctions
- immunological synapses
- cytosol
- nucleoplasm
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SKAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of adaptive immune response
- positive regulation of transcription, DNA-dependent
- positive regulation of cell-matrix adhesion
- positive regulation of heterotypic cell-cell adhesion
- adaptive immune response
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of integrin activation
- positive regulation of cell-cell adhesion mediated by integrin
- T cell receptor signaling pathway
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- cytoplasm
- cytosol
- T cell receptor complex
- plasma membrane
- immunological synapse
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein phosphatase binding
- protein binding
- SH3 domain binding
- SH2 domain binding