Mrpl18 Gene Summary [Mouse]
Predicted to enable 5S rRNA binding activity. Predicted to be involved in rRNA import into mitochondrion. Located in mitochondrion. Is expressed in several structures, including brain; connective tissue; early conceptus; genitourinary system; and gut. Orthologous to human MRPL18 (mitochondrial ribosomal protein L18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mrpl18 |
| Official Name | mitochondrial ribosomal protein L18 [Source:MGI Symbol;Acc:MGI:1914931] |
| Ensembl ID | ENSMUSG00000057388 |
| Bio databases IDs | |
| Aliases | mitochondrial ribosomal protein L18 |
| Synonyms | 1010001C05Rik, HSPC071, L18mt, mitochondrial ribosomal protein L18, uL18m |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mrpl18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 5S rRNA binding
- protein binding
- Ribosomal_L18_L5e
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- MELAS syndrome
- lung squamous cell carcinoma
- squamous cell lung cancer
regulates
- HSP70
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mrpl18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA import into mitochondrion
- mitochondrial translation
- translation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- mitochondrion
- mitochondrial ribosome
- mitochondrial large ribosomal subunit
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of ribosome
- 5S rRNA binding