Hormad1 Gene Summary [Mouse]
Involved in several processes, including meiosis I cell cycle process; meiotic sister chromatid cohesion; and regulation of cell cycle process. Acts upstream of or within homologous chromosome pairing at meiosis. Located in cytoplasm and synaptonemal complex. Is expressed in several structures, including gonad. Orthologous to human HORMAD1 (HORMA domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hormad1 |
| Official Name | HORMA domain containing 1 [Source:MGI Symbol;Acc:MGI:1915231] |
| Ensembl ID | ENSMUSG00000028109 |
| Bio databases IDs | |
| Aliases | HORMA domain containing 1 |
| Synonyms | 4921522K05Rik, CT46, HORMA domain containing 1, NOHMA, RGD1564960 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hormad1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- HORMA domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- non-insulin-dependent diabetes mellitus
- Crohn disease
- male infertility
- azoospermia
- inflammatory bowel disease
- ulcerative colitis
role in cell
- colony formation by
- cell viability
- apoptosis
- formation
- meiosis
- abnormal morphology
- degradation
- aneuploidy
- degradation in
- chromosomal aberration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromosome
- synaptonemal complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hormad1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic recombination checkpoint
- meiotic cell cycle
- regulation of homologous chromosome segregation
- oogenesis
- meiotic sister chromatid cohesion
- spermatogenesis
- blastocyst development
- synaptonemal complex assembly
- meiotic DNA double-strand break formation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- synaptonemal complex
Molecular Function
What the gene product does at the molecular level
- protein binding