Fcgr3 Gene Summary [Mouse]
Enables IgG binding activity and IgG receptor activity. Acts upstream of or within several processes, including antibody-dependent cellular cytotoxicity; phagocytosis; and positive regulation of hypersensitivity. Located in external side of plasma membrane. Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to human FCGR2A (Fc gamma receptor IIa). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Fcgr3 |
| Official Name | Fc receptor, IgG, low affinity III [Source:MGI Symbol;Acc:MGI:95500] |
| Ensembl ID | ENSMUSG00000059498 |
| Bio databases IDs | |
| Aliases | Fc receptor, IgG, low affinity III |
| Synonyms | CD16, Cd32, Fc gamma 3R Alpha, Fc Gamma R3, Fc Gamma R3 Alpha, Fc gamma receptor 2A, Fc gamma receptor 2A like 1, Fc gamma receptor 2A, pseudogene 1, fc-gamma RIII, Fcgr2a, Fcgr2al1, Fcgr2a-ps1, Fcgr3a, Fc receptor, IgG, low affinity III, fcRIII, Fc γ 3R α, Fc γ R3, Fc γ R3 α, Fc γ receptor 2A, Fc γ receptor 2A like 1, Fc γ receptor 2A, pseudogene 1, fc-γ RIII, LOC100911825, LOC100912098, LOC103694909, LOC108348047 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fcgr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IgG binding
- immunoglobulin domain
- Immunoglobulin like
- IgG receptor
- receptor binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Fcgr3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- hypersensitive reaction
- neoplasia
- hypersensitivity reaction type I
- adjuvant arthritis
- experimentally induced autoimmune hemolytic anemia
- hypersensitivity reaction type II
- experimental autoimmune encephalomyelitis
- bullous pemphigoid
- anaphylaxis
role in cell
- phosphorylation in
- expression in
- production in
- number
- quantity
- activation
- cytotoxic reaction
- antibody-dependent cell-mediated cytotoxic reaction
- adhesion
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face