Kbtbd2 Gene Summary [Mouse]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within with a positive effect on several processes, including glucose metabolic process; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and response to insulin. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KBTBD2 (kelch repeat and BTB domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kbtbd2 |
| Official Name | kelch repeat and BTB (POZ) domain containing 2 [Source:MGI Symbol;Acc:MGI:2384811] |
| Ensembl ID | ENSMUSG00000059486 |
| Bio databases IDs | |
| Aliases | kelch repeat and BTB (POZ) domain containing 2 |
| Synonyms | BKLHD1, DKFZp566C134, kelch repeat and BTB domain containing 2, kelch repeat and BTB (POZ) domain containing 2, mKIAA1489 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kbtbd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- protein binding activity, bridging
- BTB/POZ domain
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kbtbd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein kinase B signaling cascade
- response to insulin stimulus
- protein K48-linked ubiquitination
- regulation of cellular response to insulin stimulus
- lipid metabolic process
- gene expression
- glucose metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm