Eif5a Gene Summary [Mouse]
This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | Eif5a |
| Official Name | eukaryotic translation initiation factor 5A [Source:MGI Symbol;Acc:MGI:106248] |
| Ensembl ID | ENSMUSG00000078812 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 5A |
| Synonyms | D19Wsu54e, eIF-4D, eIF-5A-1, eIF5AI, eIF5A lysine, eukaryotic translation initiation factor 5A, FABAS, IF5A1, Initiation factor 5a, MGC6725 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif5a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- elongation factor P domain
- S1_like
- translation elongation factor IF5A
- translation elongation factor
- U6 snRNA binding
- deoxyhypusine synthase
- protein binding
- eIF5A domain
- translation regulator
- RNA binding
Pathways
Biological processes and signaling networks where the Eif5a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Faundes-Banka syndrome
- rotator cuff injury
- psoriasis
- acute graft-vs-host disease
- myelodysplastic syndrome with isolated del(5q)
- lichen planus
- neurodevelopmental disorder
role in cell
- apoptosis
- expression in
- proliferation
- cell death
- growth
- outgrowth
- differentiation
- translation in
- function
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endomembrane system
- Nucleus
- cytosol
- nuclear pores
- nucleoli
- synapse
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif5a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translational termination
- tumor necrosis factor-mediated signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- translational elongation
- positive regulation of translational elongation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytoplasm
- membrane
- cytosol
- annulate lamellae
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- U6 snRNA binding
- protein binding
- RNA binding
- translation elongation factor activity
- ribosome binding