Mib2 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Acts upstream of or within protein ubiquitination. Located in early endosome and plasma membrane. Part of ubiquitin ligase complex. Is expressed in several structures, including 4th ventricle choroid plexus; genitourinary system; gut; hair follicle; and hemolymphoid system gland. Orthologous to human MIB2 (MIB E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Mib2 |
| Official Name | mindbomb E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:2679684] |
| Ensembl ID | ENSMUSG00000029060 |
| Bio databases IDs | |
| Aliases | mindbomb E3 ubiquitin protein ligase 2 |
| Synonyms | 2210008I11Rik, FLJ20648, LOC100128968, MIB E3 ubiquitin protein ligase 2, mindbomb E3 ubiquitin protein ligase 2, skd, SKELETROPHIN, ZZANK1, ZZZ5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mib2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZZ
- Mib_herc2
- transcription regulator
- Ankyrin repeats (many copies)
- ubiquitin protein ligase activity
- Mind bomb SH3 repeat domain
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- ankyrin binding domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- zinc finger domain
- ankyrin repeats
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- exencephaly
- non-small cell lung cancer
role in cell
- migration
- expression in
- activation in
- phosphorylation in
- development
- invasion by
- cell proliferation
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- postsynaptic region
- Plasma Membrane
- endosomes
- cytosol
- dendritic spines
- early endosomes
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mib2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Notch signaling pathway
- regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- early endosome
- ubiquitin ligase complex
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- actin binding