Ppp6c Gene Summary [Mouse]
Enables protein serine/threonine phosphatase activity. Predicted to be involved in G1/S transition of mitotic cell cycle and negative regulation of cGAS/STING signaling pathway. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in central nervous system; pancreas epithelium; and retina. Orthologous to human PPP6C (protein phosphatase 6 catalytic subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp6c |
| Official Name | protein phosphatase 6, catalytic subunit [Source:MGI Symbol;Acc:MGI:1915107] |
| Ensembl ID | ENSMUSG00000026753 |
| Bio databases IDs | |
| Aliases | protein phosphatase 6, catalytic subunit |
| Synonyms | 2310003C10Rik, LOC171121, PP6, PP6C, PPP6, protein phosphatase 6 catalytic subunit, protein phosphatase 6, catalytic subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp6c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine phosphatase
- phosphatase
- metallophosphatase superfamily, metallophosphatase domain
- Protein phosphatase 2A homologues, catalytic domain
- protein binding
- Calcineurin-like phosphoesterase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- skin basal cell carcinoma
- basal cell skin cancer
- chronic lymphocytic leukemia
- papillomatosis
- benign neoplasia
- cannabis dependence
- opioid-related disorder
role in cell
- phosphorylation in
- survival
- polyubiquitination in
- signaling in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp6c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- protein dephosphorylation
- G1/S transition of mitotic cell cycle
- COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- metal ion binding
- myosin phosphatase activity