Enah Gene Summary [Mouse]
Enables SH3 domain binding activity and profilin binding activity. Involved in actin filament organization and actin polymerization-dependent cell motility. Acts upstream of or within actin polymerization or depolymerization; cellular response to leukemia inhibitory factor; and nervous system development. Located in several cellular components, including focal adhesion; lamellipodium; and stress fiber. Is expressed in several structures, including brain; early embryo; embryo ectoderm; gonad; and limb bud. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human ENAH (ENAH actin regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Enah |
| Official Name | ENAH actin regulator [Source:MGI Symbol;Acc:MGI:108360] |
| Ensembl ID | ENSMUSG00000022995 |
| Bio databases IDs | |
| Aliases | ENAH actin regulator |
| Synonyms | ENA, ENAH actin regulator, ENAH, actin regulator, MENA, NDPP-1, Npc Derived Proline Rich Protein 1, WBP8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Enah often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ena VASP Homology 2
- WH2
- WW domain binding
- coiled-coil domain
- EVH1 domain
- protein binding
- Pleckstrin homology-like domain
- proline rich domain
- SH3-domain binding
- profilin binding
- VASP tetramerization domain
Pathways
Biological processes and signaling networks where the Enah gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- metastasis
- advanced cancer
- myopia
- epithelial cancer
- weight gain
- liver cancer
- B cell cancer
- neuroticism
role in cell
- formation
- formation in
- migration
- quantity
- expression in
- activation in
- binding in
- proliferation
- tyrosine phosphorylation in
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell junction
- Cytoplasm
- cell periphery
- postsynaptic region
- focal adhesions
- actin cytoskeleton
- actin filaments
- cell-cell contacts
- cytosol
- nuclear envelope
- growth cone
- neurites
- synapse
- actin stress fibers
- anchoring junction
- filopodia
- cell membrane leading edge
- filopodial tip
- perikaryon
- axons
- dendrites
- inhibitory synapse
- cell-cell adherens junctions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Enah gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin polymerization or depolymerization
- axon guidance
- actin polymerization-dependent cell motility
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- focal adhesion
- filopodium
- cell junction
- cytosol
- synapse
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- SH3 domain binding
- profilin binding
- WW domain binding