T Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in cardiac muscle cell myoblast differentiation and regulation of DNA-templated transcription. Acts upstream of or within several processes, including chordate embryonic development; circulatory system development; and embryonic morphogenesis. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including egg cylinder; embryo mesenchyme; future spinal cord; genitourinary system; and mesoderm. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human TBXT (T-box transcription factor T). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | T |
| Official Name | brachyury, T-box transcription factor T [Source:MGI Symbol;Acc:MGI:98472] |
| Ensembl ID | ENSMUSG00000062327 |
| Bio databases IDs | |
| Aliases | brachyury, T-box transcription factor T |
| Synonyms | Bra, Brachy, BRACHYURY, brachyury, T-box transcription factor T, BraT, cou, D17Mit170, Low, Lr, me75, SAVA, T, T1, T-box transcription factor T, T BRACHYURY, TFT, Tl2, Tl3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse T often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- aminomethyltransferase
- transcription regulator
- T-box
- double-stranded DNA binding
- nucleic acid binding
- transcription co-repressor
- DNA-binding domain of the T-box transcription factor family
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- T-box domain
Pathways
Biological processes and signaling networks where the T gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chordoma
- spine abnormality
- bone cancer
- neural tube defect
- conventional type chordoma
- spina bifida
- sacral agenesis with vertebral anomalies
- degeneration of lumbar intervertebral disc
phenotypes
- abnormal allantois morphology
- abnormal axial mesoderm morphology
- abnormal bone ossification
- abnormal cervical atlas morphology
- abnormal cervical vertebrae morphology
- abnormal dorsal aorta morphology
- abnormal embryo development
- abnormal epidermal layer morphology
- abnormal forelimb bud morphology
- abnormal head shape
- abnormal heart looping
- abnormal heart tube morphology
- abnormal limb bud morphology
- abnormal mesoderm development
- abnormal nervous system development
- abnormal neural fold formation
- abnormal neural tube morphology
- abnormal notochord morphology
- abnormal nucleus pulposus morphology
- abnormal odontoid process morphology
- abnormal pelvic girdle bone morphology
- abnormal pericardial cavity morphology
- abnormal placenta development
- abnormal posterior primitive streak morphology
- abnormal prechordal plate morphology
- abnormal primitive streak formation
- abnormal rostral-caudal axis patterning
- abnormal sacral vertebrae morphology
- abnormal somite development
- abnormal spinal cord morphology
- abnormal tail bud morphology
- abnormal tail development
- abnormal tail morphology
- abnormal vertebral arch development
- abnormal vertebral body morphology
- absent allantois
- absent anus
- absent forelimb buds
- absent hindlimb buds
- absent notochord
- absent primitive node
- absent somites
- absent tail
- absent tail bud
- absent vertebrae
- absent vertebral body
- bleb
- caudal body truncation
- cervical vertebral fusion
- curly tail
- decreased body size
- decreased caudal vertebrae number
- decreased embryo size
- decreased litter size
- decreased presacral vertebrae number
- decreased rib number
- decreased ventral ectodermal ridge size
- delayed heart development
- distended pericardium
- edema
- embryonic growth arrest
- embryonic growth retardation
- embryonic lethality
- embryonic lethality between implantation and somite formation complete penetrance
- embryonic lethality between somite formation and embryo turning complete penetrance
- embryonic lethality during organogenesis complete penetrance
- embryonic lethality during organogenesis incomplete penetrance
- embryonic lethality complete penetrance
- failure of heart looping
- fusion of vertebral arches
- hemopericardium
- hemorrhage
- incomplete caudal neuropore closure
- incomplete embryo turning
- incomplete somite formation
- kinked neural tube
- kinked tail
- neonatal lethality incomplete penetrance
- notochord degeneration
- open neural tube
- perinatal lethality incomplete penetrance
- postnatal lethality
- prenatal lethality
- prenatal lethality complete penetrance
- preweaning lethality incomplete penetrance
- reduced male fertility
- rib fusion
- short ribs
- short tail
- spina bifida occulta
- split notochord
- thin tail
- thoracic vertebral fusion
- vertebral fusion
- vestigial tail
role in cell
- proliferation
- expression in
- cell death
- apoptosis
- cell viability
- quantity
- differentiation
- transactivation in
- endothelialization
- conversion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse T gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anterior/posterior axis specification, embryo
- signal transduction
- mesoderm development
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- cardiac muscle cell myoblast differentiation
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- heart morphogenesis
- somitogenesis
- mesoderm formation
- cell fate specification
- primitive streak formation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity