Tbxt Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in cellular response to retinoic acid. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human TBXT (T-box transcription factor T). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbxt |
| Official Name | T-box transcription factor T [Source:RGD Symbol;Acc:1310141] |
| Ensembl ID | ENSRNOG00000012229 |
| Bio databases IDs | |
| Aliases | T-box transcription factor T |
| Synonyms | Bra, Brachy, BRACHYURY, brachyury, T-box transcription factor T, BraT, cou, D17Mit170, Low, Lr, me75, SAVA, T, T1, T-box transcription factor T, T BRACHYURY, TFT, Tl2, Tl3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tbxt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- aminomethyltransferase
- transcription regulator
- T-box
- double-stranded DNA binding
- nucleic acid binding
- transcription co-repressor
- DNA-binding domain of the T-box transcription factor family
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- T-box domain
Pathways
Biological processes and signaling networks where the Tbxt gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chordoma
- spine abnormality
- bone cancer
- neural tube defect
- conventional type chordoma
- spina bifida
- sacral agenesis with vertebral anomalies
- degeneration of lumbar intervertebral disc
role in cell
- proliferation
- expression in
- cell death
- apoptosis
- cell viability
- quantity
- differentiation
- transactivation in
- endothelialization
- conversion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tbxt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anterior/posterior axis specification, embryo
- signal transduction
- mesoderm development
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- cardiac muscle cell myoblast differentiation
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- heart morphogenesis
- somitogenesis
- mesoderm formation
- cell fate specification
- primitive streak formation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity