Syt9 Gene Summary [Mouse]
Enables SNARE binding activity; identical protein binding activity; and phospholipid binding activity. Involved in calcium-dependent activation of synaptic vesicle fusion and regulation of calcium ion-dependent exocytosis. Located in dense core granule. Is active in hippocampal mossy fiber to CA3 synapse and synaptic vesicle membrane. Is expressed in several structures, including adrenal gland; gonad; liver; nervous system; and spleen. Orthologous to human SYT9 (synaptotagmin 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syt9 |
| Official Name | synaptotagmin IX [Source:MGI Symbol;Acc:MGI:1926373] |
| Ensembl ID | ENSMUSG00000062542 |
| Bio databases IDs | |
| Aliases | synaptotagmin IX |
| Synonyms | LOC143425, Synaptogamin 5, SYNAPTOTAGMIN 9, synaptotagmin IX, Syt ix, SYTV |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Syt9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- phospholipid binding
- binding protein
- phosphatidylinositol-4,5-bisphosphate binding
- transmembrane domain
- protein binding
- Protein kinase C conserved region 2 (CalB)
- identical protein binding
- transporter
- C2 domain
Pathways
Biological processes and signaling networks where the Syt9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- endocytic vesicle membrane
- synaptic membrane
- synaptic vesicles
- synapse
- secretory granules
- perikaryon
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Syt9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion-dependent exocytosis
- regulation of calcium ion-dependent exocytosis
Cellular Component
Where in the cell the gene product is active
- exocytic vesicle
- clathrin-coated endocytic vesicle membrane
- synaptic vesicle membrane
- dense core granule
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylserine binding
- identical protein binding
- protein binding
- calcium ion binding
- clathrin binding
- SNARE binding
- calcium-dependent phospholipid binding