SYT9 Gene Summary [Human]
Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Predicted to be involved in calcium-ion regulated exocytosis; cellular response to calcium ion; and regulation of secretion by cell. Predicted to be located in clathrin-coated endocytic vesicle membrane. Predicted to be active in hippocampal mossy fiber to CA3 synapse; plasma membrane; and secretory vesicle. Predicted to be integral component of synaptic vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | SYT9 |
| Official Name | synaptotagmin 9 [Source:HGNC Symbol;Acc:HGNC:19265] |
| Ensembl ID | ENSG00000170743 |
| Bio databases IDs | |
| Aliases | synaptotagmin 9 |
| Synonyms | LOC143425, Synaptogamin 5, SYNAPTOTAGMIN 9, synaptotagmin IX, Syt ix, SYTV |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SYT9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- phospholipid binding
- binding protein
- phosphatidylinositol-4,5-bisphosphate binding
- transmembrane domain
- protein binding
- Protein kinase C conserved region 2 (CalB)
- identical protein binding
- transporter
- C2 domain
Pathways
Biological processes and signaling networks where the SYT9 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- endocytic vesicle membrane
- synaptic membrane
- synaptic vesicles
- synapse
- secretory granules
- perikaryon
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SYT9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion-dependent exocytosis
- regulation of calcium ion-dependent exocytosis
Cellular Component
Where in the cell the gene product is active
- exocytic vesicle
- clathrin-coated endocytic vesicle membrane
- synaptic vesicle membrane
- dense core granule
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylserine binding
- identical protein binding
- protein binding
- calcium ion binding
- clathrin binding
- SNARE binding
- calcium-dependent phospholipid binding