Stxbp5 Gene Summary [Mouse]
Enables syntaxin-1 binding activity. Involved in positive regulation of exocytosis; regulation of synaptic vesicle exocytosis; and regulation of synaptic vesicle priming. Acts upstream of or within exocytosis and regulation of exocytosis. Part of acetylcholine-gated channel complex. Is active in hippocampal mossy fiber to CA3 synapse and presynapse. Is extrinsic component of neuronal dense core vesicle membrane. Orthologous to human STXBP5 (syntaxin binding protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stxbp5 |
| Official Name | syntaxin binding protein 5 (tomosyn) [Source:MGI Symbol;Acc:MGI:1926058] |
| Ensembl ID | ENSMUSG00000019790 |
| Bio databases IDs | |
| Aliases | syntaxin binding protein 5 (tomosyn) |
| Synonyms | 0710001E20Rik, 4930565N16RIK, LGL3, LLGL3, LOC100507593, mKIAA1006, Nbla04300, syntaxin binding protein 5, syntaxin binding protein 5 (tomosyn), tomosyn, TOMOSYN-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stxbp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- syntaxin-1 binding
- WD40
- protein binding
- SNARE motif
- LLGL2
- syntaxin binding
Pathways
Biological processes and signaling networks where the Stxbp5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tuberculosis
- venous thromboembolism
- venous thrombosis
- hypertension
- idiopathic scoliosis
- Alzheimer disease
- coronary artery disease
- ischemic stroke
- bronchopulmonary dysplasia
- tinnitus
role in cell
- binding in
- development
- priming
- exocytosis by
- membrane fusion
- excitatory postsynaptic potential
- paired-pulse facilitation
- exocytosis
- synaptic strength
- long-term potentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosolic synaptosomal fraction
- synaptic plasma membrane fractions
- low-density microsomal fraction
- presynaptic regions
- postsynaptic region
- cellular membrane
- Plasma Membrane
- cytosol
- presynaptic membrane
- synaptic vesicles
- neuromuscular junctions
- synapse
- secretory granules
- perikaryon
- detergent-soluble fraction
- synaptic vesicle fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stxbp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synaptic vesicle priming
- protein transport
- regulation of synaptic vesicle exocytosis
- Golgi to plasma membrane transport
- regulation of exocytosis
- exocytosis
- positive regulation of exocytosis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- synaptic vesicle
- SNARE complex
- cytosol
- acetylcholine-gated channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- syntaxin binding
- syntaxin-1 binding
- GTPase activator activity
- myosin II binding