Tlr12 Gene Summary [Mouse]
Predicted to enable signaling receptor activity. Acts upstream of or within defense response to protozoan. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TLR12P (toll like receptor 12, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tlr12 |
| Official Name | toll-like receptor 12 [Source:MGI Symbol;Acc:MGI:3045221] |
| Ensembl ID | ENSMUSG00000062545 |
| Bio databases IDs | |
| Aliases | toll-like receptor 12 |
| Synonyms | Gm1365, RGD1559145, Tlr11, toll-like receptor 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tlr12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- SEFIR domain
- Leucine rich repeat
- Leucine Rich repeats (2 copies)
Pathways
Biological processes and signaling networks where the Tlr12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Colorectal Cancer Metastasis Signaling
- Communication between Innate and Adaptive Immune Cells
- Neuroinflammation Signaling Pathway
- Parkinson's Signaling Pathway
- Phagosome Formation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by bacteria
phenotypes
- decreased body length
- abnormal macrophage physiology
- increased susceptibility to bacterial infection
role in cell
- function
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cellular membrane