Ncs1 Gene Summary [Mouse]
Predicted to enable several functions, including calcium sensitive guanylate cyclase activator activity; metal ion binding activity; and voltage-gated calcium channel activity. Predicted to be involved in several processes, including positive regulation of calcium-mediated signaling; regulation of exocytosis; and regulation of presynaptic cytosolic calcium ion concentration. Predicted to act upstream of or within positive regulation of synaptic transmission. Located in axon and dendrite. Is expressed in brain; dorsal root ganglion; and spinal cord. Orthologous to human NCS1 (neuronal calcium sensor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncs1 |
| Official Name | neuronal calcium sensor 1 [Source:MGI Symbol;Acc:MGI:109166] |
| Ensembl ID | ENSMUSG00000062661 |
| Bio databases IDs | |
| Aliases | neuronal calcium sensor 1 |
| Synonyms | 9430075O15Rik, A730032G13RIK, FLUP, FREQ, Frequenin homolog, Mfreq, neuronal calcium sensor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- EF-hand, calcium binding motif
- EF-hand domain
- protein kinase binding
- EF-hand domain pair
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- calcium ion binding
- EFh
- calcium-dependent protein kinase inhibitor activity
- protein binding
- magnesium ion binding
Pathways
Biological processes and signaling networks where the Ncs1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- bipolar disorder
- preeclampsia
- ulcerative colitis
- COVID-19
- tuberculosis
- insomnia
- Alzheimer disease
role in cell
- synaptic transmission
- cell death
- signaling in
- exocytosis
- survival
- loss
- development
- exocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- endoplasmic reticulum fraction
- Golgi-enriched fraction
- membrane fraction
- glutaminergic synapse
- intracellular membrane-bounded organelle
- Cytoplasm
- cell periphery
- perinuclear region
- postsynaptic region
- cellular membrane
- Nucleus
- vesicles
- Golgi Apparatus
- cytosol
- trans face of the Golgi apparatus
- Golgi stacks
- dendritic spines
- spine apparatus
- neurites
- secretory granules
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- presynaptic terminals
- vesicle fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion transmembrane transport
- regulation of neuron projection development
Cellular Component
Where in the cell the gene product is active
- dendrite
- postsynaptic density
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- Golgi apparatus
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- calcium sensitive guanylate cyclase activator activity
- voltage-gated calcium channel activity