Capn1 Gene Summary [Mouse]
Enables calcium-dependent cysteine-type endopeptidase activity. Acts upstream of or within mammary gland involution; proteolysis; and receptor catabolic process. Located in cytosol; lysosome; and mitochondrion. Is active in cornified envelope. Is expressed in liver; molar; oral region epithelium; and skin. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to human CAPN1 (calpain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Capn1 |
| Official Name | calpain 1 [Source:MGI Symbol;Acc:MGI:88263] |
| Ensembl ID | ENSMUSG00000024942 |
| Bio databases IDs | |
| Aliases | calpain 1 |
| Synonyms | CALCIUM ACTIVATED NEUTRAL PROTEASE, Calpain-1, CALPAIN I, CANP, CANP 1, CANPL1, Capa-1, MU-CALPAIN, mu-calpin, muCANP, muCL, SPG76 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Capn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- The penta-EF hand (PEF) family
- Calpain family cysteine protease
- cytoskeletal protein binding
- calpain
- peptidase
- calcium ion binding
- enzyme binding
- EFh
- protein binding
- Calpain_III
- CysPc
Pathways
Biological processes and signaling networks where the Capn1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Amyotrophic Lateral Sclerosis Signaling
- Apoptosis Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- FAK Signaling
- Huntington's Disease Signaling
- Integrin Signaling
- Mitochondrial Dysfunction
- Mitotic Roles of Polo-Like Kinase
- nNOS Signaling in Neurons
- Regulation of Cellular Mechanics by Calpain Protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- diabetes mellitus
- autosomal recessive spastic paraplegia type 76
- atopic dermatitis
- late-phase allergic reaction
- neurodegeneration
- thrombosis
- streptozotocin induced type1 diabetes
role in cell
- autophagy in
- expression in
- apoptosis
- proliferation
- formation
- phosphorylation in
- growth
- activation in
- production in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cornified envelope
- ficolin-1-rich granule lumen
- presynaptic regions
- Extracellular Space
- postsynaptic region
- cellular membrane
- Nucleus
- Plasma Membrane
- lysosome
- Golgi Apparatus
- Mitochondria
- cytosol
- mitochondrial intermembrane space
- neurites
- perikaryon
- axons
- postsynaptic density
- dendritic branches
- apical processes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Capn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- self proteolysis
- mammary gland involution
- receptor catabolic process
- regulation of catalytic activity
- positive regulation of cell proliferation
- proteolysis
- regulation of macroautophagy
- regulation of N-methyl-D-aspartate selective glutamate receptor activity
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- mitochondrion
- cytosol
- extracellular region
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- calcium-dependent cysteine-type endopeptidase activity
- peptidase activity