Tcp11 Gene Summary [Mouse]
Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; protein kinase A signaling; and regulation of sperm capacitation. Located in acrosomal vesicle and sperm midpiece. Is expressed in testis. Orthologous to human TCP11 (t-complex 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tcp11 |
| Official Name | t-complex protein 11 [Source:MGI Symbol;Acc:MGI:98544] |
| Ensembl ID | ENSMUSG00000062859 |
| Bio databases IDs | |
| Aliases | t-complex protein 11 |
| Synonyms | D17Ken1, D6S230E, FPPR, t-complex 11, t-complex protein 11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tcp11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- T-complex protein 11
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- osteoarthritis
- systemic lupus erythematosus
- cervical cancer
- survival
role in cell
- expression in
- apoptosis
- migration
- proliferation
- cell cycle progression
- exocytosis by
- capacitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sperm midpiece
- sperm tail
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tcp11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- spermatogenesis
- protein kinase A signaling cascade
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- sperm midpiece
- acrosomal vesicle
- membrane
- sperm flagellum