Hacd1 Gene Summary [Mouse]
Predicted to enable enzyme binding activity; hydroxyapatite binding activity; and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Acts upstream of or within myotube differentiation; regulation of G1/S transition of mitotic cell cycle; and regulation of G2/M transition of mitotic cell cycle. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; lung; musculature; and nervous system. Human ortholog(s) of this gene implicated in congenital myopathy. Orthologous to human HACD1 (3-hydroxyacyl-CoA dehydratase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Hacd1 |
| Official Name | 3-hydroxyacyl-CoA dehydratase 1 [Source:MGI Symbol;Acc:MGI:1353592] |
| Ensembl ID | ENSMUSG00000063275 |
| Bio databases IDs | |
| Aliases | 3-hydroxyacyl-CoA dehydratase 1 |
| Synonyms | 3-hydroxyacyl-CoA dehydratase 1, CMYO11, CMYP11, LOC683916, MYONP, PTPLA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hacd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3-hydroxyacyl-CoA dehydratase
- enzyme binding
- enzyme
- protein binding
- Protein tyrosine phosphatase-like protein, PTPLA
- hydroxyapatite binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital myopathy type 11
- myopathy
- congenital myopathy
- arrhythmogenic right ventricular cardiomyopathy
- Rett syndrome
regulates
- 3-hydroxy acyl coenzyme a
- trans-2,3-dehydroacyl-coenzyme A
- enzyme
- fatty acid
- sphingolipid
- very long chain fatty acid
- d18:1/18:0 beta-hydroxy ceramide
- protein-protein complex
role in cell
- growth
- differentiation
- attachment
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hacd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty-acyl-CoA biosynthetic process
- fatty acid elongation
- very long-chain fatty acid biosynthetic process
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- 3-hydroxyacyl-CoA dehydratase activity
- protein binding