Usp31 Gene Summary [Mouse]
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be located in nucleus. Orthologous to human USP31 (ubiquitin specific peptidase 31). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp31 |
| Official Name | ubiquitin specific peptidase 31 [Source:MGI Symbol;Acc:MGI:1923429] |
| Ensembl ID | ENSMUSG00000063317 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 31 |
| Synonyms | 6330567E21RIK, mKIAA1203, ubiquitin specific peptidase 31 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp31 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
Pathways
Biological processes and signaling networks where the Usp31 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- Turner syndrome
- Klinefelter syndrome
phenotypes
- abnormal gait
- decreased body weight
- decreased circulating bilirubin level
- decreased circulating triglyceride level
- decreased exploration in new environment
- decreased grip strength
- decreased heart left ventricle size
- decreased hematocrit
- decreased lymphocyte cell number
- decreased mean corpuscular volume
- decreased spleen weight
- decreased startle reflex
- decreased total body fat amount
- hypoactivity
- impaired pupillary reflex
- increased basophil cell number
- increased circulating creatinine level
- increased circulating phosphate level
- increased eosinophil cell number
- increased lean body mass
- increased mean corpuscular hemoglobin concentration
- increased neutrophil cell number
- increased prepulse inhibition
- mydriasis
- tremors
- abnormal startle reflex
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp31 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity