Crb1 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Involved in post-embryonic retina morphogenesis in camera-type eye. Acts upstream of with a positive effect on gene expression. Acts upstream of with a negative effect on protein localization. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; establishment of bipolar cell polarity involved in cell morphogenesis; and neurogenesis. Located in several cellular components, including adherens junction; microvillus; and photoreceptor outer segment. Part of subapical complex. Is active in apical part of cell. Is expressed in several structures, including alimentary system; central nervous system; epidermis; genitourinary system; and sensory organ. Used to study Leber congenital amaurosis 8 and retinitis pigmentosa 12. Human ortholog(s) of this gene implicated in pigmented paravenous chorioretinal atrophy and retinal disease (multiple). Orthologous to human CRB1 (crumbs cell polarity complex component 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crb1 |
| Official Name | crumbs family member 1, photoreceptor morphogenesis associated [Source:MGI Symbol;Acc:MGI:2136343] |
| Ensembl ID | ENSMUSG00000063681 |
| Bio databases IDs | |
| Aliases | crumbs family member 1, photoreceptor morphogenesis associated |
| Synonyms | 7530426H14Rik, A930008G09Rik, CRB1-A, CRB1-A2, CRB1-B, CRB1-C, crumbs cell polarity complex component 1, crumbs family member 1, photoreceptor morphogenesis associated, LCA8, RP12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LamG
- Human growth factor-like EGF
- intracellular domain
- EGF domain
- protein binding
- laminin G domain
- EGF_CA
Pathways
Biological processes and signaling networks where the Crb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- depressive disorder
- retinitis pigmentosa
- retinitis pigmentosa with coats like exudates
- leber congenital amaurosis type 8
- retinitis pigmentosa 12
- autosomal recessive retinitis pigmentosa
- pigmented paravenous chorioretinal atrophy
- retinal dystrophy
- Leber congenital amaurosis type 1
regulates
- PAR6
- CDAN1
role in cell
- growth
- formation
- quantity
- formation in
- expansion
- development
- organization
- response by
- differentiation
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
- apical compartment
- cellular membrane
- intercellular junctions
- apical membrane
- photoreceptor outer segments
- photoreceptor inner segments
- glial cell projections
- tight junctions
- zonula adherens
- microvilli
- cone outer segments
- cell-cell adherens junctions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of light stimulus involved in visual perception
- establishment or maintenance of cell polarity
- protein localization
- heterophilic cell-cell adhesion
- cell-cell signaling
- eye photoreceptor cell development
- establishment of bipolar cell polarity involved in cell morphogenesis
- cellular response to light stimulus
- plasma membrane organization
- blood vessel remodeling
- establishment or maintenance of epithelial cell apical/basal polarity
- photoreceptor cell maintenance
- retina layer formation
- gene expression
- photoreceptor cell outer segment organization
- post-embryonic retina morphogenesis in camera-type eye
- glial cell differentiation
Cellular Component
Where in the cell the gene product is active
- adherens junction
- subapical complex
- microvillus
- apical junction complex
- macromolecular complex
- photoreceptor inner segment
- extracellular region
- plasma membrane
- apical plasma membrane
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding