Crb1 Gene Summary [Rat]
Predicted to enable calcium ion binding activity. Predicted to be involved in establishment or maintenance of epithelial cell apical/basal polarity and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to act upstream of with a positive effect on gene expression. Predicted to act upstream of with a negative effect on protein localization. Predicted to act upstream of or within several processes, including detection of light stimulus involved in visual perception; eye morphogenesis; and neurogenesis. Located in microvillus and photoreceptor inner segment. Human ortholog(s) of this gene implicated in pigmented paravenous chorioretinal atrophy and retinal disease (multiple). Orthologous to human CRB1 (crumbs cell polarity complex component 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crb1 |
| Official Name | crumbs cell polarity complex component 1 [Source:RGD Symbol;Acc:1309947] |
| Ensembl ID | ENSRNOG00000010903 |
| Bio databases IDs | |
| Aliases | crumbs cell polarity complex component 1 |
| Synonyms | 7530426H14Rik, A930008G09Rik, CRB1-A, CRB1-A2, CRB1-B, CRB1-C, crumbs cell polarity complex component 1, crumbs family member 1, photoreceptor morphogenesis associated, LCA8, RP12 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Crb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LamG
- Human growth factor-like EGF
- intracellular domain
- EGF domain
- protein binding
- laminin G domain
- EGF_CA
Pathways
Biological processes and signaling networks where the Crb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- depressive disorder
- retinitis pigmentosa
- retinitis pigmentosa with coats like exudates
- leber congenital amaurosis type 8
- retinitis pigmentosa 12
- autosomal recessive retinitis pigmentosa
- pigmented paravenous chorioretinal atrophy
- retinal dystrophy
- Leber congenital amaurosis type 1
regulates
- PAR6
- CDAN1
role in cell
- growth
- formation
- quantity
- formation in
- expansion
- development
- organization
- response by
- differentiation
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
- apical compartment
- cellular membrane
- intercellular junctions
- apical membrane
- photoreceptor outer segments
- photoreceptor inner segments
- glial cell projections
- tight junctions
- zonula adherens
- microvilli
- cone outer segments
- cell-cell adherens junctions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Crb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of light stimulus involved in visual perception
- establishment or maintenance of cell polarity
- protein localization
- heterophilic cell-cell adhesion
- cell-cell signaling
- eye photoreceptor cell development
- establishment of bipolar cell polarity involved in cell morphogenesis
- cellular response to light stimulus
- plasma membrane organization
- blood vessel remodeling
- establishment or maintenance of epithelial cell apical/basal polarity
- photoreceptor cell maintenance
- retina layer formation
- gene expression
- photoreceptor cell outer segment organization
- post-embryonic retina morphogenesis in camera-type eye
- glial cell differentiation
Cellular Component
Where in the cell the gene product is active
- adherens junction
- subapical complex
- microvillus
- apical junction complex
- macromolecular complex
- photoreceptor inner segment
- extracellular region
- plasma membrane
- apical plasma membrane
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding