Cntln Gene Summary [Mouse]
Predicted to enable protein domain specific binding activity; protein kinase binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within several processes, including regulation of protein localization; single fertilization; and spermatogenesis. Is active in sperm head-tail coupling apparatus. Orthologous to human CNTLN (centlein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cntln |
| Official Name | centlein, centrosomal protein [Source:MGI Symbol;Acc:MGI:2443104] |
| Ensembl ID | ENSMUSG00000038070 |
| Bio databases IDs | |
| Aliases | centlein, centrosomal protein |
| Synonyms | B430108F07Rik, bA340N12.1, C9orf101, C9orf39, centlein, centlein, centrosomal protein, D530005L17Rik, LOC103695261, RGD1308101 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cntln often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RecF/RecN/SMC N terminal domain
- chromosome segregation protein SMC, common bacterial type
- Apg6 coiled-coil region
- protein kinase binding
- Synaptonemal complex protein 1 (SCP-1)
- protein binding activity, bridging
- protein domain specific binding
- helix-rich Mycoplasma protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- COVID-19
- acute myeloid leukemia
- insomnia
- lung adenocarcinoma
- lung adenocarcinoma formation
- alcohol use disorder
- major depression
- hemolytic anemia
- anorexia nervosa
regulates
- protein-protein complex
- RAB3IP
role in cell
- accumulation in
- ciliogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- centriole
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cntln gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centriole-centriole cohesion
- protein localization to organelle
Cellular Component
Where in the cell the gene product is active
- centrosome
- extracellular vesicular exosome
- cytoplasm
- centriole
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein domain specific binding
- protein binding, bridging