Galns Gene Summary [Mouse]
Enables N-acetylgalactosamine-6-sulfatase activity. Predicted to be involved in chondroitin sulfate proteoglycan catabolic process. Is active in lysosome. Is expressed in embryo; lens epithelium; neural retina; and retina. Used to study mucopolysaccharidosis IV. Human ortholog(s) of this gene implicated in mucopolysaccharidosis IVA. Orthologous to human GALNS (galactosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Galns |
| Official Name | galactosamine (N-acetyl)-6-sulfate sulfatase [Source:MGI Symbol;Acc:MGI:1355303] |
| Ensembl ID | ENSMUSG00000015027 |
| Bio databases IDs | |
| Aliases | galactosamine (N-acetyl)-6-sulfate sulfatase |
| Synonyms | CHONDROITINASE ABC, galactosamine (N-acetyl)-6-sulfatase, galactosamine (N-acetyl)-6-sulphatase, GalN6S, GALNAC6S, GAS, LOC105371408, mFLJ00319, MPS4A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Galns often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- Domain of unknown function (DUF4976)
- sulfuric ester hydrolase
- N-acetylgalactosamine-6-sulfatase
- Sulfatase
- enzyme
- N-acetylgalactosamine-4-sulfatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- mucopolysaccharidosis, MPS-IV-A
- mucopolysaccharidosis type IV
- hereditary disorder
- sunburn
- skeletal dysplasia
- mucopolysaccharidosis type I
- atypical femur fracture
role in cell
- quantity
- proliferation
- density
- extension
- binding in
- expression in
- phosphorylation in
- differentiation
- function
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- azurophil granule lumen
- Extracellular Space
- lysosome
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Galns gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- lysosomal lumen
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- N-acetylgalactosamine-4-sulfatase activity
- metal ion binding
- sulfuric ester hydrolase activity
- N-acetylgalactosamine-6-sulfatase activity
- arylsulfatase activity